abstract：OBJECTIVES:We sought to investigate the impact of left ventricular (LV) pacing site on mechanical response to cardiac resynchronization therapy (CRT) in patients with ischemic cardiomyopathy (ICM). BACKGROUND:CRT reduces morbidity and mortality in patients with dyssynchronous LV failure; however, variability in respon...

journal_title：Journal of the American College of Cardiology

authors： Spragg DD,Dong J,Fetics BJ,Helm R,Marine JE,Cheng A,Henrikson CA,Kass DA,Berger RD

更新日期：2010-08-31 00:00:00

abstract：:The new Adult Treatment Panel guidelines will be published in 2011. This paper suggests the consideration of major changes in the existing management guidelines for low-density lipoprotein cholesterol management based on 2 fundamental principles: return the low-density lipoprotein cholesterol level to the normal range...

journal_title：Journal of the American College of Cardiology

authors： Forrester JS

更新日期：2010-08-17 00:00:00

abstract：OBJECTIVES:The aim of this study was to assess the influence of enrolling site location and enrollment performance on the generalizability of STICH (Surgical Treatment for Ischemic Heart Failure) trial results. BACKGROUND:The international STICH trial seeks to define the role of cardiac surgery for patients with ische...

journal_title：Journal of the American College of Cardiology

authors： Jones RH,White H,Velazquez EJ,Shaw LK,Pietrobon R,Panza JA,Bonow RO,Sopko G,O'Connor CM,Rouleau JL

更新日期：2010-08-03 00:00:00

abstract：OBJECTIVES:This study investigates alterations in myocardial microvasculature, fibrosis, and hypertrophy before and after mechanical unloading of the failing human heart. BACKGROUND:Recent studies demonstrated the pathophysiologic importance and significant mechanistic links among microvasculature, fibrosis, and hyper...

journal_title：Journal of the American College of Cardiology

authors： Drakos SG,Kfoury AG,Hammond EH,Reid BB,Revelo MP,Rasmusson BY,Whitehead KJ,Salama ME,Selzman CH,Stehlik J,Clayson SE,Bristow MR,Renlund DG,Li DY

更新日期：2010-07-27 00:00:00

abstract：OBJECTIVES:The aim of this study was to determine whether single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is an effective method of risk stratification for sudden cardiac death (SCD) in patients with coronary artery disease (CAD) and left ventricular ejection fraction (LVEF)>35%. ...

journal_title：Journal of the American College of Cardiology

authors： Piccini JP,Starr AZ,Horton JR,Shaw LK,Lee KL,Al-Khatib SM,Iskandrian AE,O'Connor CM,Borges-Neto S

更新日期：2010-07-13 00:00:00

abstract：OBJECTIVES:The aim of this study was to determine which combination therapy in patients with hypertension and diabetes most effectively decreases cardiovascular events. BACKGROUND:The ACCOMPLISH (Avoiding Cardiovascular Events Through COMbination Therapy in Patients Living With Systolic Hypertension) trial compared th...

journal_title：Journal of the American College of Cardiology

authors： Weber MA,Bakris GL,Jamerson K,Weir M,Kjeldsen SE,Devereux RB,Velazquez EJ,Dahlöf B,Kelly RY,Hua TA,Hester A,Pitt B,ACCOMPLISH Investigators.

更新日期：2010-06-29 00:00:00

abstract：OBJECTIVES:We examined compliance with performance measures for 14,464 patients enrolled from July 2008 through June 2009 into the American College of Cardiology's PINNACLE (Practice Innovation And Clinical Excellence) program to provide initial insights into the quality of outpatient cardiac care. BACKGROUND:Little i...

journal_title：Journal of the American College of Cardiology

authors： Chan PS,Oetgen WJ,Buchanan D,Mitchell K,Fiocchi FF,Tang F,Jones PG,Breeding T,Thrutchley D,Rumsfeld JS,Spertus JA

更新日期：2010-06-29 00:00:00

abstract：OBJECTIVES:The aim of this study was to examine the effect of PCSK9 R46L on low-density lipoprotein cholesterol (LDL-C), risk of ischemic heart disease (IHD), and mortality. BACKGROUND:The 46L allele has been associated with reductions in LDL-C and risk of IHD, but results vary between studies. METHODS:We determined ...

journal_title：Journal of the American College of Cardiology

authors： Benn M,Nordestgaard BG,Grande P,Schnohr P,Tybjaerg-Hansen A

更新日期：2010-06-22 00:00:00

abstract：OBJECTIVES:The purpose of this study was to establish the prognostic value of measuring heart fatty acid-binding protein (H-FABP) in patients with suspected acute coronary syndrome (ACS) (in particular, low- to intermediate-risk patients), in addition to troponin measured with the latest third-generation troponin assay...

journal_title：Journal of the American College of Cardiology

authors： Viswanathan K,Kilcullen N,Morrell C,Thistlethwaite SJ,Sivananthan MU,Hassan TB,Barth JH,Hall AS

更新日期：2010-06-08 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate the relative impact of demographic and clinical variables versus the cytochrome P450 2C19 (CYP2C19) polymorphism on antiplatelet effects of clopidogrel. BACKGROUND:Platelet responses to clopidogrel show a marked interindividual variability with substantial impact on cli...

journal_title：Journal of the American College of Cardiology

authors： Hochholzer W,Trenk D,Fromm MF,Valina CM,Stratz C,Bestehorn HP,Büttner HJ,Neumann FJ

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:This study was designed to assess the risk of significant bleeding complications in patients receiving antiplatelet or anticoagulation medications at the time of implantable cardioverter-defibrillator (ICD) device implantation. BACKGROUND:Periprocedural management of antiplatelet or anticoagulation therapy ...

journal_title：Journal of the American College of Cardiology

authors： Tompkins C,Cheng A,Dalal D,Brinker JA,Leng CT,Marine JE,Nazarian S,Spragg DD,Sinha S,Halperin H,Tomaselli GF,Berger RD,Calkins H,Henrikson CA

更新日期：2010-05-25 00:00:00

abstract：OBJECTIVES:We sought to determine the relationship between atrial fibrillation (AF) ablation efficacy, quality of life (QoL), and AF-specific symptoms at 2 years. BACKGROUND:Although the primary goal of AF ablation is QoL improvement, this effect has yet to be demonstrated in the long term. METHODS:A total of 502 sym...

journal_title：Journal of the American College of Cardiology

authors： Wokhlu A,Monahan KH,Hodge DO,Asirvatham SJ,Friedman PA,Munger TM,Bradley DJ,Bluhm CM,Haroldson JM,Packer DL

更新日期：2010-05-25 00:00:00

abstract：OBJECTIVES:The aim of this randomized, single-blind, controlled trial was to assess N-acetylcysteine effects on contrast-induced nephropathy and reperfusion injury in ST-segment elevation myocardial infarction patients undergoing primary angioplasty with moderate contrast volumes. BACKGROUND:High-dose N-acetylcysteine...

journal_title：Journal of the American College of Cardiology

authors： Thiele H,Hildebrand L,Schirdewahn C,Eitel I,Adams V,Fuernau G,Erbs S,Linke A,Diederich KW,Nowak M,Desch S,Gutberlet M,Schuler G

更新日期：2010-05-18 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate whether multiple biomarkers contribute to improved coronary heart disease (CHD) risk prediction in post-menopausal women compared with assessment using traditional risk factors (TRFs) only. BACKGROUND:The utility of newer biomarkers remains uncertain when added to pr...

journal_title：Journal of the American College of Cardiology

authors： Kim HC,Greenland P,Rossouw JE,Manson JE,Cochrane BB,Lasser NL,Limacher MC,Lloyd-Jones DM,Margolis KL,Robinson JG

更新日期：2010-05-11 00:00:00

abstract：:Despite the wide contemporary availability of pharmacological and mechanical means of reperfusion, a very significant proportion of ST-segment elevation myocardial infarction (STEMI) patients are still not offered any reperfusion therapy, and some of them are considered "ineligible for reperfusion." Spontaneous reperf...

journal_title：Journal of the American College of Cardiology

authors： Cohen M,Boiangiu C,Abidi M

更新日期：2010-05-04 00:00:00

abstract：OBJECTIVES:We hypothesized that an amlodipine-based regimen would have more favorable effects on left ventricular (LV) diastolic function. BACKGROUND:Different antihypertensive therapies may vary in their effect on LV diastolic function. METHODS:The HACVD (Hypertension Associated Cardiovascular Disease) substudy of A...

journal_title：Journal of the American College of Cardiology

authors： Tapp RJ,Sharp A,Stanton AV,O'Brien E,Chaturvedi N,Poulter NR,Sever PS,Thom SA,Hughes AD,Mayet J,ASCOT Investigators.

更新日期：2010-04-27 00:00:00

abstract：OBJECTIVES:The purpose of this study was to investigate whether omega-3 polyunsaturated fatty acids (PUFAs) are able to modify platelet responsiveness to dual antiplatelet therapy in stable coronary artery disease patients undergoing percutaneous coronary intervention (PCI). BACKGROUND:Although previous studies have s...

journal_title：Journal of the American College of Cardiology

authors： Gajos G,Rostoff P,Undas A,Piwowarska W

更新日期：2010-04-20 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate the efficacy and safety of mipomersen in hypercholesterolemic subjects taking stable statin therapy. BACKGROUND:Mipomersen is an apolipoprotein (apo) B synthesis inhibitor that has demonstrated significant reductions in apo B and low-density lipoprotein (LDL) cholestero...

journal_title：Journal of the American College of Cardiology

authors： Akdim F,Stroes ES,Sijbrands EJ,Tribble DL,Trip MD,Jukema JW,Flaim JD,Su J,Yu R,Baker BF,Wedel MK,Kastelein JJ

更新日期：2010-04-13 00:00:00

abstract：OBJECTIVES:The aim of this study was to determine the impact of delay to angioplasty in patients with acute coronary syndromes (ACS). BACKGROUND:There is a paucity of data on the impact of delays to percutaneous coronary intervention (PCI) in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) u...

journal_title：Journal of the American College of Cardiology

authors： Sorajja P,Gersh BJ,Cox DA,McLaughlin MG,Zimetbaum P,Costantini C,Stuckey T,Tcheng JE,Mehran R,Lansky AJ,Grines CL,Stone GW

更新日期：2010-04-06 00:00:00

abstract：OBJECTIVES:We sought to determine whether the introduction of these agents had altered the outcome of dilated cardiomyopathy (DC) in childhood. BACKGROUND:Pediatric DC has a poor prognosis. Angiotensin-converting enzyme inhibitors (ACEIs) and beta-adrenergic receptor blockers (BBs) improve survival in adults with DC, ...

journal_title：Journal of the American College of Cardiology

authors： Kantor PF,Abraham JR,Dipchand AI,Benson LN,Redington AN

更新日期：2010-03-30 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate gene expression networks related to cardiovascular disease in radiated human arteries. BACKGROUND:Recent epidemiological studies have shown that radiotherapy is associated with cardiovascular disease years after treatment. However, the molecular mechanisms underlying...

journal_title：Journal of the American College of Cardiology

authors： Halle M,Gabrielsen A,Paulsson-Berne G,Gahm C,Agardh HE,Farnebo F,Tornvall P

更新日期：2010-03-23 00:00:00

abstract：OBJECTIVES:The aim of this study was to understand the initial mechanism of arterial thrombus formation induced by vulnerable human atherosclerotic plaques to re-assess and improve current antithrombotic strategies. BACKGROUND:Rupture of atherosclerotic plaques causes arterial thrombus formation that might lead to myo...

journal_title：Journal of the American College of Cardiology

authors： Reininger AJ,Bernlochner I,Penz SM,Ravanat C,Smethurst P,Farndale RW,Gachet C,Brandl R,Siess W

更新日期：2010-03-16 00:00:00

abstract：OBJECTIVES:The aim of this study was to determine whether the carotid/brachial (C/B) ratio is an independent predictor of cardiovascular (CV) risk. BACKGROUND:Brachial and carotid pulse pressure (PP) are independent predictors of CV risk, mainly in elderly patients. Because PP is physiologically lower at the brachial ...

journal_title：Journal of the American College of Cardiology

authors： Benetos A,Thomas F,Joly L,Blacher J,Pannier B,Labat C,Salvi P,Smulyan H,Safar ME

更新日期：2010-03-09 00:00:00

abstract：OBJECTIVES:This study investigated whether ranolazine reduces dofetilide-induced torsades de pointes (TdP) in a model of long QT syndrome with down-regulated K(+) currents due to hypertrophic remodeling in the dog with chronic atrioventricular block (cAVB). BACKGROUND:Ranolazine inhibits the late Na(+) current (I(NaL)...

journal_title：Journal of the American College of Cardiology

authors： Antoons G,Oros A,Beekman JD,Engelen MA,Houtman MJ,Belardinelli L,Stengl M,Vos MA

更新日期：2010-02-23 00:00:00

abstract：OBJECTIVES:The aim of this multicenter study was to evaluate the safety of discontinuing oral anticoagulation therapy (OAT) after apparently successful pulmonary vein isolation. BACKGROUND:Atrial fibrillation (AF) is associated with an increased risk of thromboembolic events (TE) and often requires OAT. Pulmonary vein...

journal_title：Journal of the American College of Cardiology

authors： Themistoclakis S,Corrado A,Marchlinski FE,Jais P,Zado E,Rossillo A,Di Biase L,Schweikert RA,Saliba WI,Horton R,Mohanty P,Patel D,Burkhardt DJ,Wazni OM,Bonso A,Callans DJ,Haissaguerre M,Raviele A,Natale A

更新日期：2010-02-23 00:00:00

abstract：OBJECTIVES:This study was designed to investigate whether the addition of N-terminal pro-B-type natriuretic peptide-guided, intensive patient management (BM) to multidisciplinary care (MC) improves outcome in patients following hospitalization due to heart failure (HF). BACKGROUND:Patients hospitalized due to HF exper...

journal_title：Journal of the American College of Cardiology

authors： Berger R,Moertl D,Peter S,Ahmadi R,Huelsmann M,Yamuti S,Wagner B,Pacher R

更新日期：2010-02-16 00:00:00

abstract：OBJECTIVES:This study sought to determine the association of high ankle brachial index (ABI) measurements with left ventricular (LV) mass, and to compare its strength with that of low ABI with LV mass. BACKGROUND:Arterial stiffness leads to LV mass through nonatherosclerotic pathways in mice. In humans, a high ABI ind...

journal_title：Journal of the American College of Cardiology

authors： Ix JH,Katz R,Peralta CA,de Boer IH,Allison MA,Bluemke DA,Siscovick DS,Lima JA,Criqui MH

更新日期：2010-01-26 00:00:00

abstract：:The appropriateness and timing of mitral valve surgery in patients with advanced heart failure and severe mitral regurgitation remains controversial. Recent surgical results provide evidence for beneficial effects on left ventricular remodeling and functional capacity. Given the absence of randomized trials comparing ...

journal_title：Journal of the American College of Cardiology

authors： Di Salvo TG,Acker MA,Dec GW,Byrne JG

更新日期：2010-01-26 00:00:00

abstract：OBJECTIVES:This meta-analysis was performed to determine the effects of various cholesterol-lowering treatments on the risk of stroke and its relationship with the extent of cholesterol lowering. BACKGROUND:Statins reduce the incidence of stroke, and it has been proposed that such effect is independent of cholesterol ...

journal_title：Journal of the American College of Cardiology

authors： De Caterina R,Scarano M,Marfisi R,Lucisano G,Palma F,Tatasciore A,Marchioli R

更新日期：2010-01-19 00:00:00

abstract：OBJECTIVES:The aim of this study was to determine the effects of physical activity on systemic blood pressure (BP) and early markers of atherosclerosis in pre-pubertal obese children. BACKGROUND:Hypertension and endothelial dysfunction are premature complications of obesity. METHODS:We performed a 3-month randomized ...

journal_title：Journal of the American College of Cardiology

authors： Farpour-Lambert NJ,Aggoun Y,Marchand LM,Martin XE,Herrmann FR,Beghetti M

更新日期：2009-12-15 00:00:00

abstract：OBJECTIVES:The aim of this study was to compare the pulmonary artery (PA) growth after arterial duct (AD) stenting versus modified Blalock-Taussig shunt (MBTS) in neonates with congenital heart disease with duct-dependent pulmonary circulation (CHD-DPC). BACKGROUND:Arterial duct stenting is increasingly deemed a relia...

journal_title：Journal of the American College of Cardiology

authors： Santoro G,Capozzi G,Caianiello G,Palladino MT,Marrone C,Farina G,Russo MG,Calabrò R

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVES:This prospective study evaluated the association of obesity and hypertension with left atrial (LA) volume over 10 years. BACKGROUND:Although left atrial enlargement (LAE) is an independent risk factor for atrial fibrillation, stroke, and death, little information is available about determinants of LA size i...

journal_title：Journal of the American College of Cardiology

authors： Stritzke J,Markus MR,Duderstadt S,Lieb W,Luchner A,Döring A,Keil U,Hense HW,Schunkert H,MONICA\/KORA Investigators.

更新日期：2009-11-17 00:00:00

abstract：:Kawasaki disease (KD) is an acute, self-limited vasculitis that typically occurs in young children and was first described by Japanese pediatrician Tomisaku Kawasaki in 1967. Although originally thought to be a rare condition, KD has become the most common cause of acquired heart disease in the pediatric age group in ...

journal_title：Journal of the American College of Cardiology

authors： Gordon JB,Kahn AM,Burns JC

更新日期：2009-11-17 00:00:00

abstract：OBJECTIVES:The purpose of this study was to determine whether intrinsic histological abnormalities of the pulmonary trunk (PT) are present from birth and interact with palliative surgery and/or repair. BACKGROUND:Little is known about PT histology in patients with tetralogy of Fallot (TOF), especially in the era of su...

journal_title：Journal of the American College of Cardiology

authors： Bédard E,McCarthy KP,Dimopoulos K,Giannakoulas G,Gatzoulis MA,Ho SY

更新日期：2009-11-10 00:00:00

abstract：OBJECTIVES:Our aim was to assess the predictive value of myocardial infarct size assessed with late gadolinium-enhanced (LGE) magnetic resonance imaging (MRI) in medically treated patients with chronic myocardial infarction relative to contractile reserve on low-dose dobutamine magnetic resonance (DSMR) for long-term e...

journal_title：Journal of the American College of Cardiology

authors： Kelle S,Roes SD,Klein C,Kokocinski T,de Roos A,Fleck E,Bax JJ,Nagel E

更新日期：2009-11-03 00:00:00

abstract：OBJECTIVES:We sought to identify single nucleotide polymorphisms associated with mild statin-induced side effects. BACKGROUND:Statin-induced side effects can interfere with therapy. Single nucleotide polymorphisms in cytochrome P450 enzymes impair statin metabolism; the reduced function SLCO1B1*5 allele impairs statin...

journal_title：Journal of the American College of Cardiology

authors： Voora D,Shah SH,Spasojevic I,Ali S,Reed CR,Salisbury BA,Ginsburg GS

更新日期：2009-10-20 00:00:00

abstract：OBJECTIVES:The purpose of this study was to assess the ability of plasma B-type natriuretic peptide (BNP) to diagnose significant cardiovascular disease (CVD) in the pediatric population. BACKGROUND:BNP has been shown to be reliable in detecting ventricular dysfunction and heart failure in adults. Timely and accurate ...

journal_title：Journal of the American College of Cardiology

authors： Law YM,Hoyer AW,Reller MD,Silberbach M

更新日期：2009-10-06 00:00:00

abstract：OBJECTIVES:This study sought to examine quality of care and warfarin use at discharge in patients with atrial fibrillation (AF) and heart failure (HF). BACKGROUND:Atrial fibrillation is common in HF, and national guidelines recommend discharge on warfarin for stroke prophylaxis. However, the frequency and factors asso...

journal_title：Journal of the American College of Cardiology

authors： Piccini JP,Hernandez AF,Zhao X,Patel MR,Lewis WR,Peterson ED,Fonarow GC,Get With The Guidelines Steering Committee and Hospitals.

更新日期：2009-09-29 00:00:00

abstract：OBJECTIVES:This study sought to determine the association of chronic kidney disease (CKD) with high ankle brachial index (ABI) measurement and to compare its strength with that of CKD with a low ABI. BACKGROUND:CKD is an important risk factor for cardiovascular disease (CVD) events. A high ABI, a marker of lower extre...

journal_title：Journal of the American College of Cardiology

authors： Ix JH,Katz R,De Boer IH,Kestenbaum BR,Allison MA,Siscovick DS,Newman AB,Sarnak MJ,Shlipak MG,Criqui MH

更新日期：2009-09-22 00:00:00

abstract：OBJECTIVES:The purpose of the study was to determine the independent and additive prognostic value of brain natriuretic peptide (BNP) in patients with severe asymptomatic mitral regurgitation and normal left ventricular function. BACKGROUND:Early surgery could be advisable in selected patients with chronic severe mitr...

journal_title：Journal of the American College of Cardiology

authors： Pizarro R,Bazzino OO,Oberti PF,Falconi M,Achilli F,Arias A,Krauss JG,Cagide AM

更新日期：2009-09-15 00:00:00